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Chemistry of Drugs (New Chemistry)

Drug development and research offer some of the most challenging and exciting research in the field of chemistry. "Chemistry of Drugs" provides an introduction to the most common processes by which chemists design and develop drugs today. It describes the chemical principles on which those processes are based, along with an overview of the applications and hazards associated with a variety of drugs available both legally and illegally.Coverage also includes attempts to find and develop new natural products for use as drugs; the potential for curing diseases, such as cancer; the growing field of biotechnology; and combinational chemistry, a method of producing, evaluating, and developing new chemical compounds with possible value as drugs. Designer drugs are also discussed, as well as important social, economic, and political issues related to the development and use of drugs. Biographical information on many influential figures involved in the advancement of this field throughout history completes this enlightening volume.

Principles of Organic Medicinal Chemistry

The book Principles of Organic Medicinal Chemistry describes the principles and concepts of chemistry, synthetic schemes, structure activity relationships, mechanism of action and clinical uses of carbon compounds in the light of modern trends. The book covers the syllabi of B.Pharmacy and M.Pharmacy courses of all Indian Universities.

This book comprises of 22 chapters. Chapter 1 gives an introduction to medicinal chemistry, Chapter 2 explain about the basics on principles of drug action and physicochemical properties of organic medicinal, substances are elaborated in Chapter 3. The concepts of Prodrugs and Drug metabolism are summarized in Chapter 4 and Chapter 5 respectively. Chapter 6 to Chapter 22 explains chemistry, properties, mechanism of action, structure activity relationships, chemistry of newer drugs and clinical uses of various therapeutic agents. At the end of book, a set of more than 200 essays and short questions and 225 objective questions with answers are strategically designed.

Business Development for the Biotechnology and Pharmaceutical Industry

Business Development in the Biotechnology and pharmaceutical industries accounts for over $5 billion in licensing deal value per year and much more than that in the value of mergers and acquisitions. Transactions range from licences to patented academic research, to product developments as licences, joint ventures and acquisition of intellectual property rights, and on to collaborations in development and marketing, locally or across the globe. Asset sales, mergers and corporate take-overs are also a part of the business development remit. The scope of the job can be immense, spanning the life-cycle of products from the earliest levels of research to the disposal of residual marketing rights, involving legal regulatory manufacturing, clinical development, sales and marketing and financial aspects.The knowledge and skills required of practitioners must be similarly broad, yet the availability of information for developing a career in business development is sparse. Martin Austin's highly practical guide spans the complete process and is based on his 30 years of experience in the industry and the well-established training programme that he has developed and delivers to pharmaceutical executives from across the world.

The BMA Family Doctor Home Adviser

A complete quick reference to symptoms and how to deal with them. It includes sections on how the body works; maintaining health and fitness for all the family; first aid; and common medical tests. There are diagnostic charts and illustrations that detail anatomy and medical procedures.

Medical Writing: A Prescription for Clarity

Effective communication is the ultimate, but often daunting, purpose of any piece of medical research. Medical Writing: A Prescription for Clarity provides practical information enabling first drafts to be turned into clear, simple, unambiguous text, without loss of individuality. Written by a medical consultant and an experienced medical editor, it is sympathetic to the problems and needs of medical writers. Like the preceding two editions, this expanded third edition deals with the basic craft of writing for publication, from spelling and grammar to choosing the best word or phrase. Whether writing a simple clinical report or thesis, wanting to supervise others, or wanting just to develop greater skill in effective writing, this book is the ideal guide and reference. Clear, simple and precise, and illustrated with apt cartoons, this is an invaluable handbook.

Contemporary Drug Synthesis

An integrated and insightful look at successful drug synthesis in today’s drug discovery market

The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug.

Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume:

Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Pharmacology Recall

Written with the busy medical student and house officer in mind, Pharmacology Recall minimizes the time spent reading and identifying important material and maximizes the time available for actual learning. As part of Lippincott Williams & Wilkins' Recall Series, Pharmacology Recall uses the concise, two-column question-and-answer format to facilitate quick learning. Common Board questions and mnemonics appear throughout the book to facilitate memorization and illustrations are provided to clarify important concepts. As an additional aid, a Pharmacology Power Review is included. This chapter presents a unique "bird's eye" view of pharmacology and can be used to review large amounts of high-yield information quickly before medical school and USMLE exams.

Advances in Clinical Chemistry (v. 19)

For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology, informatics, and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.


Starch, Third Edition: Chemistry and Technology

The third edition of this long-serving successful reference work is a 'must-have' reference for anyone needing or desiring an understanding of the structure, chemistry, properties, production and uses of starches and their derivatives. 

* Everything needed to evaluate and apply the appropriate starch-based solution
* Explores the genetics, biochemistry, and physical structure of starches
* Includes specific information on corn, wheat, potato, rice, rye, oat and barley-based starches
* Presents new application trends for starch

Chemical Engineering Magazine - April 2009

34Cover Story Achema Defies Economic Odds Even in a recession year, over 180,000 visitors from 100 countries are anticipated at this triennial event


13Chementator This new crystallizer reduced damage to larger crystals; Sonopolymerization as a means to manufacture composite nanoparticles; Reduce process consumables with this new separator; A less expensive way to make conductive coatings; A new standard for viscosity measurement; High-throughput screening accelerates glycerolto-chemicals research; A palladium catalyst makes primary amines in aqueous NH3; Optical fiber sensing gets an NSF boost; EPA proposes national reporting system for greenhouse gases; and more

24Newsfront Recycling Cathode Ray Tubes As CRTs become an obsolete form of video display technology, recycling their lead-filed glass is increasingly important

28Newsfront Digital Handover Headaches Electronic project handover has helped, but standardization with data and system compatibility remain


37Facts At Your Fingertips Energy Efficiency In Steam Systems This one-page guide explains the importance of efficient condensate handling in steam systems

42Feature Report Optimizing Pumping Systems Often overlooked, pump system efficiency makes a dramatic impact on process performance

46Feature Report Calculate Capital Costs Quickly Estimating capital costs early can prevent wasting money on dead-end projects

53Solids Processing Understanding Bends In Pneumatic Conveying Systems Despite their apparent simplicity, bends are often poorly understood and unless properly designed, they are potentially problematic


40D-1, 40I-1Show Preview Achema Achema 2009 (Frankfurt am Main, Germany; May 11–15), the World’s largest assembly of chemical process industry professionals is approaching. With over 200,000 visitors and more than 3,500 exhibitors filling the exhibition grounds of Messe Frankfurt GmbH, this exhibition and congress on chemical engineering, environmental protection and biotechnology continues to be the flagship trade fair for the chemical process industries. This show preview contains a cross-section of the products and services that will be on display

61Focus Temperature Measurement & Control This three-way valve improves temperature control; Field-ready portable temperature monitor features three scales; Get industrial boiler measurements for consistent blowdown control; This module delivers a wide range of capabilities for temperature control; Measure flowrate and temperature with one instrument; New infrared sensor offers improved performance in harsh industrial environments; and more


5Editor’s Page Achema maintains influence This month, instead of focusing on a single comprehensive story or even a two-part series, our cover highlights Achema 2009, an important thread that weaves throughout the issue and beyond. 


Look for: Feature Reports on Design and Operation of Gravity Dryers; and Chemical Process Safety; Engineering Practice articles on Optimal Cooling Systems for Coastal Plants; ERP Packaging for Your EPC Contracting Business; and Treatment of Wastewater in a Delayed Coking Unit; A Focus on Heat Transfer; News articles on Batch Processing; and Petroleum Refining; Facts at Your Fingertips on Process Control; and more

New Animal Models of Human Neurological Diseases

This publication describes in detail some animal models of outstanding importance for the study of human neurological diseases. An introductory article provides a definition of animal models, looks at the history and ethics of their use, and highlights the reasons why animal models are so useful in scientific research. The following chapters present some of the newer models which play a key role in the study of amyotrophic lateral sclerosis, multiple sclerosis, stroke and peripheral neuropathy. Their specific features are detailed in the method section of each paper, and their application to the study of human neurological diseases is discussed in a comprehensive manner, i.e. limits and challenges posed by these models are evaluated and potential improvements suggested. 
A valuable single source of information, this book is recommended reading for neuroscientists as well as for neurologists and neurosurgeons interested in preclinical research on human neurological diseases.

Lippincott's Illustrated Reviews: Pharmacology, 4th Edition

Lippincott's Illustrated Reviews: Pharmacology, Fourth Edition enables rapid review and assimilation of large amounts of complex information about the essentials of medical pharmacology. Clear, sequential pictures of mechanisms of action actually show students how drugs work, instead of just telling them. As in previous editions, the book features an outline format, over 500 full-color illustrations, cross-references to other volumes in the series, and over 125 review questions. Content has been thoroughly updated, and a new chapter covers toxicology. New to this edition will be a companion Website containing all of the illustrations, fully searchable text, and an interactive question bank.


FASTtrack: Pharmaceutics - Dosage Form and Design

This is a revision guide for students giving bullet points of basic information on pharmaceutics - dosage form and design. "FASTtrack" is a new series of indispensable study guides created especially for undergraduate pharmacy students.The content of each title focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs, case studies, sample essay questions and worked examples.This title follows on from the "FASTtrack: Physical Pharmacy" book by David Attwood and Alexander T Florence covering information on the formulation, what components are used and the dosage form. In addition, this title will complement "FASTtrack: Pharmaceutics - Delivery and Taregting" by Yvonne Perrie and Thomas Rades. The "FASTtrack" series provides the ultimate lecture notes and is a must-have for all pharmacy undergraduate students wanting to revise and test themselves for forthcoming exams. A FASTtrack website includes MCQs, sample online content and much more.

Dietary Supplements Pocket Companion

This is a pocket companion based on the "MRW, Dietary Supplements". 88 monographs are arranged alphabetically. How to use this book section will be rewritten. The introduction is omitted and aims to use the same symbols as in "Stockley's Pocket Companion".Based on the MRW, Dietary Supplements, this pocket companion will cover truncated versions of the 82 monographs in the large reference work with an additional 6 monographs (88 in total). Monographs will be listed alphabetically and will contain: brief description, constituents, human requirements, dietary sources, action, possible uses (in tabular form), bioavailability, precautions/contraindications, pregnancy and breast-feeding, adverse effects, interactions, dose and brief references (no more than ten per monograph). This title will therefore be a concise, quick reference for health professionals and will include a brief assessment of the latest evidence.

International Research in Healthcare

This book is an essential guide for those thinking of undertaking a multi-centre research project. Research across international boundaries presents challenges with the need to consider relevance of research objectives and feasibility of procedures in different settings whilst maintaining scientific integrity in terms of design, instruments and execution.

Progress in Medicinal Chemistry : Volume 29

Hardbound. The 29th volume of the series presents yet again, an exemplary survey of a wide range of current topics in medicinal chemistry and pharmacology. Eight expert reviews emphasize the relationships between chemical structure and pharmacological activity. These detailed discussions of some of the most exciting developments in the field today, will prove of great value to future research. The book begins with a study of anti-inflammatory activities of 5-lipoxygenase inhibitors, followed by an overview of the antiarrhythmic therapeutic possibilities offered by Class III electrophysiological agents. Structures and activities of some opioid ligands are surveyed, and the investigation into pharmacologically active pyridazine derivatives is continued. Dopamine D2 receptor agonists offer exciting therapeutic potential, as do ondansetron and related 5-HT3 antagonists. The herbal origin of many modern drugs is yet again reflected in a survey.


Applied Pharmaceutical Practice

This is a comprehensive guide through the main stages of pharmaceutical dispensing.The textbook is designed to guide student pharmacists or pharmacy technicians through the main stages involved in pharmaceutical dispensing. It provides students with a core reference text to accompany the compulsory dispensing course found in all pharmacy undergraduate programmes, highlighting and explaining all key concepts behind the processes involved in pharmaceutical dispensing.


Essentials of Pharmaceutical Chemistry, 3rd Edition

It covers the core information required by pharmacy students to understand the action of modern drugs on the human body.The third edition is larger than the previous edition and includes a new chapter on licensing of drugs and medicines which describes the make up and function of important committees such as the Commission of Human Medicines and the British Pharmacopoeia Commission. This includes material that is within the public domain and explains the process of getting a drug to market.The majority of the chapters include more worked examples/tutorial examples and the chapter on Analytical spectroscopy has been updated to include "qualitative" spectroscopic methods especially NMR, mass spectroscopy and some IR and the chapter on Stability of drugs and medicines has been updated to include a major section on "prodrugs" which are inactive compounds designed to decompose within the body to release the active moiety.


Introduction to Statistics in Pharmaceutical Clinical Trials

This book is a self-contained introduction to Statistics, presented in the context of clinical trials and pharmaceutical drug development. It focuses on the statistical analyses most commonly used in drug development and is therefore an ideal introduction to pharmaceutical statistics. Instead of introducing a series of statistical techniques, the book's organizational structure follows the order in which numerical information and statistical analyses are used in trials and new drug development.All students taking classes in pharmaceutical sciences and clinical research need a solid knowledge and understanding of the nature, methods, application and importance of Statistics. They need to understand:why, and how data are collected in clinical trials; how these data are summarized and analyzed; what the results mean in the context of the clinical research question; and, how the results are communicated to regulatory agencies and to scientific and medical communities.This title therefore adopts a unique approach and concept in organization of the content. It begins with an introduction to statistical theory, analysis and interpretation. This is followed by a discussion of t-tests and confidence intervals. Readers are then taken through the whole process of new drug development (using one specific example throughout) that is meaningful in the context of their broader studies. Throughout this process, statistical techniques and analyses are introduced in the order in which they are employed during the process.The book's realistic scientific and progressive organization from pre-clinical trials to clinical pharmacology through clinical trials is novel, meaningful and educationally powerful. The book emphasises the importance of descriptive statistics as well as inferential statistics, something that is rarely done.Supplementary material is included for this text on the PharmPress website in the form of PowerPoint lecture notes on Statistics (based on content of this book) that can be downloaded by lecturers.