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Medical Statistics: A Guide to Data Analysis and Critical Appraisal

This hands-on guide is much more than a basic medical statistics introduction. It equips you with the statistical tools required for evidence-based clinical research.

Each chapter provides a clear step-by-step guide to each statistical test with practical instructions on how to generate and interpret the numbers, and present the results as scientific tables or graphs.

Applied Pharmacology for Veterinary Technicians

Designed specifically for veterinary technicians, this essential resource offers detailed guidance on key topics such as managing medication inventory, dispensing veterinarian prescribed drugs, calculating drug dosages, administering medications to animals, and educating clients about drug side effects and precautions. 

Up-to-date drug information is presented in a consistent, easy-to-use format that includes pharmacokinetics, pharmacodynamics, clinical uses, dosage forms, and adverse side effects. Illustrated, step-by-step procedures demonstrate proper administration techniques for common drug forms.

Forecasting for the Pharmaceutical Industry: Models for New Product And In-market Forecasting And How to Use Them

In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month's production schedule, to market estimates for drugs in the next decade. 

The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex 'black box' equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Art Cook's highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. 

The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. "Forecasting for the Pharmaceutical Industry" is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making.

Advances in Food and Nutrition Research Volume 41 Starch: Basic Science to Biotechnology

This volume presents the physiological and biochemical aspects of storage carbohydrates, or starch granules, in plants. This up-to-date and thorough resource carefully integrates fundamental knowledge with the most recent information on the starch granule. 

It discusses the chemistry of the starch granule and the biochemistry, molecular biology, plant physiology, and genetics of plant starch synthesis. The books also describes the implications of these studies for theseed, biotechnology, and modified starch industries.

Gareth Thomas, "Medicinal Chemistry: An Introduction"

Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field.

Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth.

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

In response to the US FDA’s Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the principles and latest statistical methodologies used when modifying trial procedures based on accrued data of ongoing clinical trials. The book also gives a well-balanced summary of current regulatory perspectives. 

The first several chapters focus on the fundamental theory behind adaptive trial design, the application of the Bayesian approach to adaptive designs, and the impact of potential population shift due to protocol amendments. The book then presents a variety of statistical methods for group sequential design, classical design, dose-finding trials, Phase I/II and Phase II/III seamless adaptive designs, multiple stage seamless adaptive trial design, adaptive randomization trials, hypotheses-adaptive design, and treatment-adaptive design. It also covers predictive biomarker diagnostics for new drug development, clinical strategies for endpoint selection in translational research, the role of independent data monitoring committees in adaptive clinical trials, the enrichment process in targeted clinical trials for personalized medicine, applications of adaptive designs that use genomic or genetic information, adaptive trial simulation, and the efficiency of adaptive design. The final chapters discuss case studies as well as standard operating procedures for good adaptive practices.

With contributions from leading clinical researchers in the pharmaceutical industry, academia, and regulatory agencies, this handbook offers an up-to-date, complete treatment of the principles and methods of adaptive design and analysis. Along with reviewing recent developments, it examines issues commonly encountered when applying adaptive design methods in clinical trials.

Progress in Inorganic Chemistry, Dithiolene Chemistry: Synthesis, Properties, and Applications

"Dithiolene metal complexes have a history going back to the 1960's (at least). But, interest in such compounds faded by the seventies. However, there has been a major resurgence, just in the last very few years, and a number of research groups have found exciting new properties (i.e., photochemistry, luminescence), applications as sensors and new materials of industrial interest. 

Moreover, very recent (in the last five years, or less) biochemical insights have revealed that dithiolene-metal complexes exist in nature, in certain enzyme active sites. Thus, a segment of the biochemical and (bio)inorganic chem istry community is currently devoting considerable attention to inorganic synthetic, theoretical and other aspects of dithiolene coordination chemistry."

The Design and Manufacture of Medical Devices

Medical devices are included in the fields of medical and health technology and encompass a wide range of health care products. Today, it is difficult to obtain an exact definition of "medical device." Directive 2007/47/EC, for example, defines a medical device as, "any instrument, apparatus, appliance, software, material or other article, whether used alone or in combination, including the software intended by its manufacturer to be used specifically for diagnostic and/or therapeutic purposes and necessary for its proper application, intended by the manufacturer to be used for human beings." 

This book brings together a range of articles and case studies dealing with medical device R&D. Chapters cover materials used in medical implants, such as Titanium Oxide, polyurethane, and advanced polymers; devices for specific applications such as spinal and craniofacial implants, and other issues related to medical devices, such as precision machining and integrated telemedicine systems.