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Encyclopedia of Molecular Pharmacology, 2nd edition

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.


Ultraviolet Light in Water and Wastewater Sanitation

Several general books are available on ultraviolet light and its applications. However, this is the first comprehensive monograph that deals with its application to water and wastewater treatment. There is a rapidly growing interest in using UV light in water sanitation due to the increased knowledge of the potential health and environmental impacts of disinfection byproducts. Ultraviolet Light in Water and Wastewater Sanitation integrates the fundamental physics applicable to water and wastewater sanitation, the engineering aspects, and the practical experience in the field. The text analyzes the concerns associated with this application of UV light and brings together comprehensive information on the presently available UV technologies applicable to water and wastewater treatment including: lamp technologies, criteria of evaluation and choice of technology; fundamental principles; performance criteria for disinfection; design criteria and methods; synergistic use of UV and oxidants (advanced oxidation); and functional requirements and potential advantages and drawbacks of the technique. Ultraviolet Light in Water and Wastewater Sanitation is the only treatise currently available combining fundamental knowledge, recommendations for design, evaluations of performance, and future prospects for this application. Water and wastewater treatment professionals, water utility employees, governmental regulators, and chemists will find this book an essential and unique reference for a technology which has received growing regulatory acceptance.


Coatings Technology Handbook, Third Edition

Completely revised and updated, the Coatings Technology Handbook, Third Edition supplies a broad cross-index of the different aspects involved in the discipline. Containing 14 new chapters, the book covers the composition of both organic and inorganic resins, pigments or fillers, and additives, from polymeric fluorocarbons to water borne, solvent-borne, and one hundred percent non-volatile compounds. It examines the testing of raw materials and products and shows dyes used in inks with formulation data. This edition includes a new chapter on specialty pigments for high temperature unique to this book, a chapter on statistical experimentation, a chapter on regulations, and a chapter on formulations with a spreadsheet of formulation calculations. This resource expands your awareness and knowledge of coatings, inks, and adhesives, aids you in problem solving, and increases your level of familiarity with the technology.


Hansen Solubility Parameters: A User's Handbook, Second Edition

Hansen solubility parameters (HSPs) are used to predict molecular affinities, solubility, and solubility-related phenomena. Revised and updated throughout, Hansen Solubility Parameters: A User's Handbook, Second Edition features the three Hansen solubility parameters for over 1200 chemicals and correlations for over 400 materials including polymers, inorganic salts, and biological materials.

To update his groundbreaking handbook with the latest advances and perspectives, Charles M. Hansen has invited five renowned experts to share their work, theories, and practical applications involving HSPs. New discussions include a new statistical thermodynamics approach for confirming existing HSPs and how they fit into other thermodynamic theories for polymer solutions. Entirely new chapters examine the prediction of environmental stress cracking as well as absorption and diffusion in polymers. Highlighting recent findings on interactions with DNA, the treatment of biological materials also includesskin tissue, proteins, natural fibers, and cholesterol. The book also covers the latest applications of HSPs, such as ozone-safe “designer” solvents, protective clothing, drug delivery systems, and petroleum applications.

Presenting a comprehensive survey of the theoretical and practical aspects of HSPs, Hansen Solubility Parameters, Second Edition concludes with a detailed discussion on the necessary research, future directions, and potential applications for which HSPs can provide a useful means of prediction in areas such as biological materials, controlled release applications, nanotechnology, and self-assembly.

Handbook of Water Treatment, 2nd English Edition

In the area of water treatment and process treatment chemicals, we have made technological improvements to ensure efficient operation and contribute to water and energy conservation in various water systems. We have also addressed critical issues surrounding water system treatment, such as the reduction of environmental impact through the development of non-phosphorus boiler compounds, non-hydrazine oxygen scavengers, and low- or non-phosphorus cooling water treatment chemicals. In addition, we have focused on the important task of ensuring work safety and chemical-handling safety. Our efforts have been rewarded with ISO 9001 and ISO 14001 certifications. We believe that these certifications are proof of our commitment to quality assurance for our products, and to environmental preservation and improvement. In order to introduce some of our company's innovative technology and accomplishments in the field of water treatment chemicals to a global readership, we published the first English edition of our handbook in 1985. Since then, we have continued working to develop more advanced technology and improved products. In this second edition, we have described our technologies and products in as much detail as possible, to ensure that we provide our readers with useful data.

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Drug Development Process: Increasing Efficiency & Cost Effectiveness

Containing contributions from the many disciplines involved in a drug's evolution, this timely volume examines the entire pharmaceutical development process, emphasizing approaches to increasing efficiency and reducing costs.


Pharmaceutical Preformulation

Book addresses problems and solutions of formulation and preformulation with which I have concerned myself for 34 years. When I was employed in the pharmaceutical industry I worked at functions, in the 1960's, which were the precursors of preformulation, and my early publications dealt with such matters. In the following decades advances have been made in methodology and the realm of preformulation has grown. Theory and the way in which problems are viewed have also undergone change. The text deals with the pharmaceutical aspects of preformulation, not the synthetic nor the analytical aspects. It takes its vantage point at the point in time when the pharmaceutical preformulator first obtains a sample of the drug substance, and it explores the physical, chemical and technological aspects that are needed for a full exploration of the potential advantages and disadvantages of the drug substance. It is only through the understanding of underlying principles that adequate exploration can be carried out.


Pharmacokinetics: Regulatory, Industrial, Academic Perspectives

Offering a unique, multidisciplinary approach, this state-of-the-art Second Edition details the rapidly changing role that clinical and non-clinical pharmacokinetics and drug metabolism play in the discovery and development of drug therapies -- emphasizing often overlooked regulatory, scientific, and economic issues.


Parenteral Quality Control

This second edition details current methods of testing parenteral quality control and discusses new techniques and emerging trends. It combines principles with practical information on how the tests are conducted, their strengths and limitations, and possible forthcoming changes. Coverage includes global testing requirements; new issues and approaches involving retesting of lots that failed initial sterility tests; and new technologies such as barrier systems for conducting sterility testing.


Handbook of Pharmaceutical Granulation Technology

This practical guide integrates the basic principles and current industrial practices of pharmaceutical granulation production;discussing state-of-the-art technologies and demonstrating cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements.


Pharmaceutical Project Management

Drawing on the experience of project managers from international pharmaceutical companies, this work reviews up-to-date strategic, operational and organizational procedures for drug development in today's competitive industry. It includes details of how target product profiles are established and used to direct drug development; and project definition and risk management, including analytical techniques and asset valuation at the project and portfolio levels.


Pharmaceutical Dosage Forms: Tablets, Vol. 2

H.H. Lieberman Associates, Inc., Livingston, New Jersey. 'Tablets' complete in 3 volumes. Pharmaceutical technology. 15 Contributors. DNLM: 1. Dosage forms.


Opioid Research: Methods and Protocols

Univ. of Texas MD Anderson Cancer Center, Houston. Text provides a comprehensive collection of methods and protocols used in current opioid research. Covers molecular and genetic techniques and behavioral analysis of animal models. Provides state-of-the-art techniques plus clinical applications. For researchers and practitioners.


cGMP: Generators, Effectors and Therapeutic Implications

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.


Mass Spectrometry: A Textbook

This book is tailored for students and professionals as well as novices from other fields to mass spectrometry, an indispensable tool in chemistry and life sciences. It will guide them from the basics to the successful application of mass spectrometry in their daily research. Starting from the very principles of gas-phase ion chemistry and isotopic properties, it leads through the design of mass analyzers and ionization methods in use to mass spectral interpretation and coupling techniques. Step by step the readers will learn how mass spectrometry works and what it can do as a powerful tool in their hands. The book comprises a balanced mixture of practice-oriented information and theoretical background. The clear layout, a wealth of high-quality figures and a database of exercises and solutions, accessible via the publisher?s web site, support teaching and learning.


Robustness of Analytical Chemical Methods and Pharmaceutical Technological Products

Hardbound. In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given.

Features of this book:

• Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry

• Illustrates the different approaches available to attain robustness

Dielectric Analysis Of Pharmaceutical Systems

Dielectric analysis is a technique used particularly in quality controlling drug samples. This guide to the dielectric analysis of pharmaceutical systems serves both as an introduction to the technique and as a spring board for further studies of Pharmaceutical Systems.


Handbook of Basic Tables for Chemical Analysis, Second Edition

If you are a researcher in organic chemistry, chemical engineering, pharmaceutical science, forensics, or environmental science, you make routine use of chemical analysis. And like its best-selling predecessor was, the Handbook of Basic Tables for Chemical Analysis, Second Edition is your one-stop source for the information needed to design chemical analyses. Here's what is new in the Second Edition:"New chapters on solutions, electroanalytical methods, electrophoresis, and laboratory safety"An expanded section on gas chromatography that includes data on compounds that attack common detectors"New information on detector optimization"An updated section on high performance liquid chromatography that provides the most recent chiral stationary phases, detector information, and revised solvent tables"Updated information on the most useful "wet" chemistry methods"Enlarged section of Miscellaneous Tables Going far beyond the landmark first edition in terms of scope and applications, the second edition provides current and updated data culled from a wide range of resources and consolidated into a concise yet easy-to-use format. The book's laser-like focus on core information gives you the knowledge you need when you need it - at the decision point.


Illustrated Pocket Dictionary of Chromatography

Provides concise definitions, illustrations, formulas, and all of the other information that you need in a laboratory chromatography reference

The Illustrated Pocket Dictionary of Chromatography offers the perfect quick reference to the parameters, systems, and components that support successful chromatographic separations. Concise, practical, and filled with detailed drawings, diagrams, and photographs, this pocket dictionary is designed for easy use in the laboratory. It provides a complete, up-to-date reference on analytical techniques such as gas chromatography, high-performance liquid chromatography, thin layer chromatography, and capillary electrophoresis as well as preparation techniques such as solid phase extraction and microextraction.

The Illustrated Pocket Dictionary of Chromatography features:

  • Explanations of key concepts
  • Equations and formulas
  • Parameters
  • High-quality photographs of instruments, equipment, and components
  • References for further research
  • Explanations of common acronyms
Ideal for the working chemist or technician in pharmaceutical, industrial, forensic, government, or other lab settings, the Illustrated Pocket Dictionary of Chromatography is also appropriate as a supplemental reference for analytical chemistry courses and labs. Students and analysts alike will find this compact yet comprehensive resource a valuable companion to their work in chromatography.


Laboratory Automation in the Chemical Industries

This timely reference explores the broad range of automated techniques being employed by chemists. Written by academics, manufacturers, and practicing chemists in the pharmaceutical and fine chemicals industries, the book covers aspects of automation in chemistry discovery and process development. It features chapters on design, implementation, and optimization of automated techniques for the synthesis, purification, production, and analysis of new pharmaceutical and chemical compounds.


Dermatologic, Cosmeceutic, and Cosmetic Development: Therapeutic and Novel Approaches

Recent advances in our understanding of the development and morphology of normal skin has led to improved methods to deliver therapeutic compounds to selected targeted areas both within the skin and systemically. This reference provides a clear overview of current pharmaceutical and cosmetic practices in the management of both major and minor skin disorders, and provides an expansive overview of novel drugs and therapies used to treat these conditions. Written for scientists interested in dermatological therapy and those concerned with the marketing for pharmaceutical and cosmetic products, this text will also prove useful for students developing strong research methods.


Essential Math and Calculations for Pharmacy Technicians

Accurately calculating medication dosages is a critical element in pharmaceutical care that directly effects optimal patient outcomes. Unfortunately, medication dosage errors happen in pharmacies, in hospitals, or even at home or in homecare settings everyday. In extreme cases, even minor dosage errors can have dire consequences. Careful calculations are essential to providing optimal medical and pharmaceutical care. Essential Math and Calculations for Pharmacy Technicians fills the need for a basic reference that students and professionals can use to help them understand and perform accurate calculations. Organized in a natural progression from the basic to the complex, the book includes:·Roman and Arabic Numerals·Fractions and decimals·Ratios, proportions, and percentages·Systems of measurement including household conversions·Interpretation of medication orders·Isotonicity, pH, buffers, and reconstitutions·Intravenous flow rates·Insulin and Heparin products·Pediatric dosage·Business mathPacked with numerous solved examples and practice problems, the book presents the math in a step-by-step style that allows readers to quickly grasp concepts. The authors explain the fundamentals simply and clearly and include ample practice problems that help readers become proficient. The focus on critical thinking, real-life problem scenarios, and the self-test format make Essential Math and Calculations for Pharmacy Technicians an indispensable learning tool.


High-Throughput Analysis in the Pharmaceutical Industry

High throughput analysis plays a critical role in the pharmaceutical industry. The ever-shortening timelines and high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the industry. Written and edited by well-known contributors who remain active in this line of research, this book systematically describes high throughput analysis for the pharmaceutical industry, including advanced instrumentation and automated sample preparation. The text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods, with an emphasis on the later stage of drug development, including pharmacokinetics.


Managing Relationships with Industry: A Physician's Compliance Manual

Physicians in academic and private practice settings are increasingly engaged in collaborations and encounters with employees and contractors from the research and marketing arms of pharmaceutical and device companies. These activities are numerous and range from consulting and conducting research, to giving talks, meeting with sales representatives, to interfacing with industry on behalf of foundations and professional societies.

The primary aim of this book is to educate physicians about the rules, regulations, and guidlines relevant to and the potential pitfalls of collaborating with industry so that physicians may enter into allowable relationships with industry with the knowledge necessary to mitigate the possible legal risks.

* Will help physicians stay abreast of the new rules for continuing medical education (CME)
* Addresses the increasing amount of international commercial, academic and clinical collaboration
* Discusses the growing and accelerating regulatory environment that defines the scope and boundaries of physician-industry relationships


Ion Exchange and Solvent Extraction: A Series of Advances, Volume 16

Presenting key advancements in the areas of ion exchange and solvent extraction on par with the high-level research consistently related by this series, Volume 16 discusses the ion-exchange isothermal supersaturation technique, metal separation via pH-induced parametric pumping, modeling of ion-exchange kinetics for ultrapure water, ion-exchange properties of engineered carbons and carbonaceous materials, and many more topics.


Pharmaceutical Dosage Forms: Tablets, Third Edition Volume 1: Unit Operations and Mechanical Properties

Pharmaceutical Dosage Forms: Tablets, Volume 1 examines the fundamental physical and chemical processes that the different unit oprations use, and then applies this knowledge to the discussion of the varying unit operations and processes.


Handbook of Industrial Mixing: Science and Practice

Handbook of Industrial Mixing will explain the difference and uses of a variety of mixers including gear mixers, top entry mixers, side entry mixers, bottom entry mixers, on-line mixers, and submerged mixers The Handbook discusses the trade-offs among various mixers, concentrating on which might be considered for a particular process. Handbook of Industrial Mixing explains industrial mixers in a clear concise manner, and also:

* Gives practical insights by the top professional in the field.

* Details applications in key industries.

* Provides the professional with information he did receive in school


Delivery System Handbook for Personal Care and Cosmetic Products : Technology, Applications and Formulations

Novel delivery systems designed to facilitate the use of “fountain of youth” and other functional actives is an idea whose time has come. In a rapidly growing global market eager for products that really work, accelerating market pull and technology push forces have set the stage for this Foundation text. This “must have” book is the first volume of a new series entitled “Breakthroughs in Personal Care and Cosmetic Technology.” It has been carefully designed for training, development, and the empowerment of synergistic technology transfer across the personal care, cosmetic, and pharmaceutical industries.

This book is intended to cause a breakthrough in effective communication and interaction among technology and marketing functions. It is a showcase for understanding, using, and marketing the technology of why and how delivery systems work, as well as current, emerging/potential applications and working formulations. Each chapter is written by one or more experts in the field. A wide range of companies serving the global marketplace are represented. These companies offer numerous types of delivery systems containing highly desirable functional actives, delivery system technology development services, and opportunities for technology licensing, mergers, and acquisitions. A unique feature of the book is the use of Mind Map™ technology to capture and present the essence of the inner-thinking of over 80 authors in a Book-at-a-Glance Executive Overview section. This section has been specifically designed to powerfully impact decision making leading to the development of innovative product differentiation in a global context.

Analytical Gas Chromatography, Second Edition

Gas chromatography remains the world's most widely used analytical technique, yet the expertise of a large proportion of chromatographers lies in other fields. Many users have little real knowledge of the variablesin the chromatographic process, the interaction between those variables, how they are best controlled, how the quality of their analytical results could be improved, and how analysis times can be shortened to facilitate the generation of a greater numberof more reliable results on the same equipment. An analyst with a more comprehensive understanding of chromatographic principles and practice, however, can often improve the quality of the data generated, reduce the analytical time, and forestall the needto purchase an additional chromatograph or another mass spectrometer.The Second Edition of Analytical Gas Chromatography is extensively revised with selected areas expanded and many new explanations and figures. The section on sample injection has been updated to include newer concepts of split, splitless, hot and cold on-column, programmed temperature vaporization, and large volume injections. Coverage of stationary phases now includes discussion, applications, and rationale of the increased thermal and oxidative resistance of the newly designed silarylenepolysiloxane polymers. Conventional and"extended range"polyethylene glycol stationary phases are examined from the viewpoints of temperature range and retention index reliabilities, and the chapter on"Variables"has been completely rewritten. The ways in which carrier gas velocity influences chromatographic performance is considered in detail, and includes what may be the first rational explanation of the seemingly anomalous effects that temperature exercises on gas viscosity (and gas flow). The practical effects that these changes cause to the chromatography is examined in pressure-, flow-, and"EPC-"regulated systems."Column Selection, Installation, and Use"has been completely rewritten as well. The accuracy of theVan Deemter plots has been greatly enhanced; a new program corrects for the first time for the changes in gas density and diffusion that occur during the chromatographic process because of solute progression through the pressure drop of the column. A new section has also been added on meeting thespecial requirements of columns destined for mass spectral analysis. The chapter on"Special Applications"has been expanded to include considerations of"selectivity tuning,"of fast analysis, and the section of Applications has been thoroughly updated and expanded.

Key Features:

* Incorporates nearly 60% new material
* Covers the newest concepts and materials for sample injection and stationary phases
* Presents detailed consideration of the influence of carrier gas velocity on practical aspects of chromatographic performance
* Contains a chapter on "Special Analytical Techniques" which includes consideration of selectivity tuning and fast analysis
* Provides a new section addressing the special requirements of columns to be used in mass spectral analysis
* Includes an improved program that greatly enhances the accuracy of the Van Deemter plots by more accurately depicting localized chromatographic conditions at each point in the column.


Basic Statistics and Pharmaceutical Statistical Applications

This extremely pragmatic and accessible reference provides scientists with a basic knowledge of statistics, focusing on the practical application of statistical methods to research, quality control, and data analysis. Basic Statistics and Pharmaceutical Statistical Applications explores types of variables, random sampling, probability, measures of central tendency, and hypothesis testing, discusses regression analysis, nonparametric tests, and power determination, and examines study designs, confidence intervals, dissolution testing, and bioequivalence. Also described are the interrelation of hypotheses, test statistics, decision rules, computations, statistical decisions and testing factors.


HVAC Equations, Data and Rules of Thumb

The most complete, most job-critical reference for the most frequently used HVAC design data describes HVAC Equations, Data, Rules of Thumb. Veteran HVAC designer Arthur Bell Jr.'s handy, superbly organized data bank follows the CSI MasterFormat.

You'll reach for this time-saving task-simplifier dozens of times every working day for: Equations - more than 216 equations for everything from ductwork to air change rates...from steel pipe, relief valve and water heater sizing to NPSH calculations, Data definitions, ASME and ASHRAE code specs, air and waterproperties, conversion factors, building construction business fundamentals, equipment manufacturers, energy conservation conditions, auxiliary equipment, designer's checklists, professional societies and organizations, and more. 358 Rules of Thumb in all for buildings of every imaginable type, from churches to cocktail lounges. Includes cooling and heating loads, infiltration, ventilation, humidification, people/occupancy, lighting,appliance/equipment, more.


Passive Sampling Techniques in Environmental Monitoring, Volume 48

Monitoring pollutants in air, soil and water is a routine requirement in the workplace, and in the wider environment. Passive samplers can provide a representative picture of levels of pollutants over a period of time from days to months by measuring the average concentrations to which they have been exposed. Air monitors are widely used, for instance to measure the exposure of workers to volatile compounds, but also for monitoring the fate of pollutants in the atmosphere. Passive sampling devices are now becomining increasingly used to monitor pollutants in rivers, coastal waters and ground water where contamination results from sources such as domestic and industrial discharges, and the use of agrochemicals.
Passive Sampling Techniques in Environmental Monitoring provides a timely collection of information on a set of techniques that help monitor the quality of air, surface and ground waters. Passive sampling can provide an inexpensive means of obtaining a representative picture of quality over a period of time, even where levels of pollutants fluctuate due to discontinuous discharges or seasonal application of chemicals such as pesticides. Recent changes in legislation have increased the pressure to obtain better information than that provided by classical infrequent spot sampling.
Brought together in one source, this book looks at the performance of a range of devices for the passive sampling of metals, and of non-polar and polar organic chemicals in air and in water. The strengths and weaknesses and the range of applicability of the technology are considered.

* Comprehensive review of passive sampling - covering air, water and majority of available technologies in one volume
* Chapters written by international specialist experts
* Covers theory and applications, providing background information and guidelines for use in the field


Clinical Trials - A Practical Guide to Design, Analysis, and Reporting

This book is a friendly jargon buster, which aims to demystify clinical trials. It is divided into five sections: fundamentals of trial design, alternative trial designs, basics of statistical analysis, special trial issues in data analysis, and reporting of trials. Using simple language the book explains with illustrations of numerous trial examples, the conceptual and methodological issues that occur at all stages of clinical trial covering trial design, conduct, analysis and reporting. The book is an educational and approachable reference in a difficult area of medicine where clinicians often feel uncertain and this material helps them review, appraise and publish trials and clinical evidence. The audience for the book includes physicians, statisticians, pharmacists, medical students, clinical researchers, medical writers, data managers, study co-ordinators, pharmaceutical sales representatives, and financial (medical) analysts.

Good Design Practices for GMP Pharmaceutical Facilities

A convenient single-source reference for anyone involved in the planning, construction, validation, and maintenance of modern pharmaceutical facilities, this guide assists project managers as they develop, diagram, and implement pharmaceutical production facility projects-demonstrating how advances in technology and external regulation can impact the production and efficacy of a pharmaceutical facility and the products it produces.


Pharmaceutical Formulation Development of Peptides and Proteins

This comprehensive volume brings the different aspects of peptide and protein formulation into focus, beginning with the fundamentals of the production of peptides and proteins, ranging from synthesis to protein purification.


Instant Notes in Analytical Chemistry

Instant Notes in Analytical Chemistry provides concise yet comprehensive coverage of analytical chemistry at an undergraduate level, providing easy access to the core information in the field. The book covers all the important areas of analytical chemistry in a format which is ideal for learning and rapid revision.

Protein Mass Spectrometry, Volume 52

This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to study of protein structure and function as well as proteomics.
It is a definite must have work for:
- libraries at academic institutions with Master and Graduate programs in Biochemistry, Molecular Biology, Structural Biology and Proteomics;
- individual laboratories with interests covering these areas; and
- libraries and individual laboratories in the pharmaceutical and biotechnology industries.

. serves as an essential reference to those working in the field
. incorporates the contributions of prominent experts
. features comprehensive coverage and a logical structure


Synthesis of Essential Drugs

This book represents an effort to express a long overdue need of compiling information which has been accumulated over the course of more than 30 years of our work in the area of the synthesis of medicinal drugs. Our effort fills obvious gaps that exist in the literature of drug synthesis.

The synthesis of various groups of drugs are presented in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind - to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists.

Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed description of methods for their synthesis.

Of the thousands of drugs existing on the pharmaceutical market, we mainly discuss generic drugs that are included in the WHO's "Essential List of Drugs."

For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms.

This book will provide the kind of information that will be of interest to those who work, or plan to begin work in the captivating areas of biologically active compounds and the synthesis of medicinal drugs.

* Provides a brief description of methods of synthesis, activity and implementation of all drug types
* Includes synonyms
* Includes over 2300 references.


Maintaining Cultures for Biotechnology and Industry

To retain their usefulness, cultures that manufacture economically valuable products must be uncontaminated, viable, and genetically stable. Maintaining Cultures for Biotechnology and Industry gives practical advice necessary to preserve and maintain cells and microorganisms important to the biotechnology and pharmaceutical industries in ways that ensure they will continue to be able to synthesize those valuable metabolites. This book covers not just those strains currently being used but also those yet to be discovered and engineered.This text is essential for anyone working with cultures who wants to avoid the frustration of losing strains and needs to be able to devise and evaluate new strategies for preservation.
Key Features
* Written by hands-on experts in their respective fields
*Contains helpful tables and protocols for preserving or maintaining cells, cultures and viruses
*Discusses means to preserve cells by freezing, lyophilization, drying, cyoprotection, spore storage, continuous propagation and subculturing when absolutely necessary, and others
*Gives information needed to test cultures for stable retention of important characteristics
*Gives principles needed to devise and evaluate preservation strategies for newly identified and newly engineered cells and organisms
*Lists culture sources for each class of organism
*Includes information for characterizing and monitoring recombinant organisms, especially important because of their propensity for genetic stability
*Discusses the history of the continually evolving field of culture preservation
*Examines the importance of genetically stable cultures as it relates to maintaining patent positions.

Modeling and Simulation of Capsules and Biological Cells

In the past three decades, considerable progress has been made in the mathematical analysis, modeling, and simulation of the fluid dynamics of liquid capsules and biological cells. In this book, leaders in the field explore topics related to the modeling and numerical simulation of capsule fluid dynamics and cell biomechanics. Providing an outstanding overview of the subject, the authors include results from their own ongoing research. The book covers the fundamentals of cell and membrane mechanics, modeling hydrodynamics under various flow conditions, and drop and bubble dynamics associated with temperature variations and surfactant transport. The clear exposition and stand-alone format provided by Modeling and Simulation of Capsules and Biological Cells puts state-of-the-art information in a single source that will undoubtedly motivate further work in this developing field.

Good Laboratory Practice: OECD Principles And Guidelines for Compliance Monitoring

This publication unites all of the OECD documents related to Good Laboratory Practice and compliance monitoring, and, in the Annex, reproduces the three OECD Council Decisions related to the Mutual Acceptance of Data in the Assessment of Chemicals. It includes the international standards for quality of non-clinical environmental, health and safety data on chemicals and chemical products in a regulatory context—the OECD Principles of Good Laboratory Practice—and supporting Consensus and Advisory Documents on their interpretation and application. The OECD guidance documents for governments on monitoring compliance with the Good Laboratory Practice Principles are also included. This publication thus presents the state of the art on Good Laboratory Practice and compliance monitoring.

Food Preservation Techniques

Text provides a review of developments in food preservation techniques and the ways they can be combined to preserve particular foods.

Martindale: The Complete Drug Reference, 35th Edition 2 Volume Set

Provides evaluated information on drugs and medicines used throughout the world.


Microbial Contamination Control in Parenteral Manufacturing

This reference surveys emerging trends, concepts, and procedures used in the characterization and control of contaminants; the sterile production of traditional drugs and biologics; the design, construction, and validation of new parenteral facilities; and the monitoring of clean environments-vividly illustrating the routes by which products, processes, and manufacturing settings become contaminated through contact with the air, water, raw materials, and the actions of personnel, as well as the current methods necessary to successfully preclude contamination.


Contamination and ESD Control in High Technology Manufacturing

A practical "how to" guide that effectively deals with the control of both contamination and ESD

This book offers effective strategies and techniques for contamination and electrostatic discharge (ESD) control that can be implemented in a wide range of high-technology industries, including semiconductor, disk drive, aerospace, pharmaceutical, medical device, automobile, and food production manufacturing. The authors set forth a new and innovative methodology that can manage both contamination and ESD, often considered to be mutually exclusive challenges requiring distinct strategies.

Beginning with two general chapters on the fundamentals of contamination and ESD control, the book presents a logical progression of topics that collectively build the necessary skills and knowledge:

  • Analysis methods for solving contamination and ESD problems
  • Building the contamination and ESD control environment, including design and construction of cleanrooms and ESD protected environments
  • Cleaning processes and the equipment needed to support these processes
  • Tooling design and certification
  • Continuous monitoring
  • Consumable supplies and packaging materials
  • Controlling contamination and ESD originating from people
  • Management of cleanrooms and ESD protected workplace environments

Contamination and ESD Control in High-Technology Manufacturing conveys a practical, working knowledge of contamination and ESD control strategies and techniques, and it is filled with case studies that illustrate key principles and the benefits of contamination and ESD control. Moreover, its straightforward style makes the material, which integrates many disciplines of engineering and science, clear and accessible.

Written by three leading industry experts, this book is an essential guide for engineers and designers across the many industries where contamination and ESD control is a concern.

Pharmacokinetics, Second Edition

Bible of Pharmacokinetics


AHFS Drug Information 2008

First published in 1959, the "Big Red Book," as it's come to be known, has gone the extra mile for pharmacists and healthcare professionals seeking answers to the most detailed questions. It provides more extensive evidence-based data than any other drug reference. AHFS DI is the only reference free from the influence of manufacturers, insurers, regulators, and other special interests, giving you an unbiased source of drug information.

if messages about scripts error bother you try this:first define the drug you want, than click on + to open all subfolder which lie in the medicine name direction, than click on + near folder Document Body Date - and choose AFHS Drug InformationB(2008) - if you will work in such way you will recieve only one message about error.