ABC Transporters and Multidrug Resistance

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.

ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

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Advances in Pharmacology and Chemotherapy: v. 7

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Advances in Pharmacology, Volume 3

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Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends

Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.

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Pharm Phlash!: Pharmacology Flash Cards

A classroom-developed, student-tested system that increases pharmacology test scores…decreases and prevents medication errors in the clinical setting…improves NCLEX pharmacology scores…and expands understanding of pharmacological agents! Inside a practical, flip-top box are 189 illustrated, test yourself review cards that cover critical clinical information for nearly 400 of the top generic medications, color-coded by body system and cross referenced by drug classification. These flash cards are not only the ideal supplement to any pharmacology or medical-surgical course, but also handy for care planning and exam prep. And, you can count on them for accuracy, because each card is based on content from Davis's Drug Guide for Nurses.

KEY FEATURES:

A color-coded, body-system organization reflects the information common to classes of medications—knowledge crucial to NCLEX success and to reducing medication errors.

- Each card features a single generic drug or a medication group, and details…action • use • pre-administration vital signs • laboratory data assessment • drug levels • patient teaching • and more.

- Drugs are cross-referenced to potential nursing diagnosis and other indications at the bottom of each card.

- Common abbreviations appear on each card, with a summary of the abbreviations on separate, introductory cards.

- A comprehensive alphabetical Index makes it easy to locate drugs within the deck by trade, generic, or Canadian brand name.

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European Pharmacopoeia 5th Ed. Main Volume 5.0, 2005

The purpose of the Pharmacopoeia is to promote public health, by the provision of recognised common standards for use by healthcare professionals and others concerned with the quality of medicines.

The monographs and other texts are designed to be appropriate to the needs of regulatory authorities, those engaged in the control of quality, and the manufacturers of starting materials and medicinal products.

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Pharmacology: Principles and Practice

This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

*Uses individual drugs to explain molecular actions

*Full color art program explains molecular and chemical concepts graphically

*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules

*Covers such intricacies as drug resistance and cell death

*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

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