Handbook Of Pharmaceutical Excipients, By Raymond C Rowe And Paul J Sheskey

Pharmaceutical dosage forms contain both pharmacologically active compounds and excipients added to aid the formulation and manufacture of the subsequent dosage form for administration to patients. Indeed, the properties of the final dosage form (i.e. its bioavailability and stability) are, for the most part, highly dependent on the excipients chosen, their concentration and interaction with both the active compound and each other.

No longer can excipients be regarded simply as inert or inactive ingredients, and a detailed knowledge not only of the physical and chemical properties but also of the safety, handling and regulatory status of these materials is essential for formulators throughout the world. In addition, the growth of novel forms of delivery has resulted in an increase in the number of the excipients being used and suppliers of excipients have developed novel excipient mixtures and new physical forms to improve their properties. The Handbook of Pharmaceutical Excipients has been conceived as a systematic, comprehensive resource of information on all of these topics

Applied Pharmacology for Veterinary Technicians

Designed specifically for veterinary technicians, this essential resource offers detailed guidance on key topics such as managing medication inventory, dispensing veterinarian prescribed drugs, calculating drug dosages, administering medications to animals, and educating clients about drug side effects and precautions. 

Up-to-date drug information is presented in a consistent, easy-to-use format that includes pharmacokinetics, pharmacodynamics, clinical uses, dosage forms, and adverse side effects. Illustrated, step-by-step procedures demonstrate proper administration techniques for common drug forms.

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Drug-Drug Interactions: Scientific and Regulatory Perspectives, Volume 43 (Advances in Pharmacology)

Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Key Features

* Provides useful references on the science of drug-drug interactions

* Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint

* Contains original data from academic and industrial laboratories

* Presents an overview of regulatory agency positions

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Advances in Pharmacology and Chemotherapy: v. 7

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Advances in Pharmacology, Volume 3

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Pharm Phlash!: Pharmacology Flash Cards

A classroom-developed, student-tested system that increases pharmacology test scores…decreases and prevents medication errors in the clinical setting…improves NCLEX pharmacology scores…and expands understanding of pharmacological agents! Inside a practical, flip-top box are 189 illustrated, test yourself review cards that cover critical clinical information for nearly 400 of the top generic medications, color-coded by body system and cross referenced by drug classification. These flash cards are not only the ideal supplement to any pharmacology or medical-surgical course, but also handy for care planning and exam prep. And, you can count on them for accuracy, because each card is based on content from Davis's Drug Guide for Nurses.

KEY FEATURES:

A color-coded, body-system organization reflects the information common to classes of medications—knowledge crucial to NCLEX success and to reducing medication errors.

- Each card features a single generic drug or a medication group, and details…action • use • pre-administration vital signs • laboratory data assessment • drug levels • patient teaching • and more.

- Drugs are cross-referenced to potential nursing diagnosis and other indications at the bottom of each card.

- Common abbreviations appear on each card, with a summary of the abbreviations on separate, introductory cards.

- A comprehensive alphabetical Index makes it easy to locate drugs within the deck by trade, generic, or Canadian brand name.

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Pharmacology: Principles and Practice

This unique and much needed textbook meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.

The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.

*Uses individual drugs to explain molecular actions

*Full color art program explains molecular and chemical concepts graphically

*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules

*Covers such intricacies as drug resistance and cell death

*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

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Pharmacy Case Studies

Whilst most pharmacy undergraduate texts are subject specific, "Pharmacy Case Studies" encourages students to take an integral approach to pharmacy via a series of pharmacy cases. Knowledge gained within the individual areas of law and ethics, pharmaceutics, pharmacology and pathology are tested by each example, bringing together all areas taught on the degree course. Each chapter contains five case studies, starting with uncomplicated cases and increasing in complexity as they expand.

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Pharmacology Recall

Written with the busy medical student and house officer in mind, Pharmacology Recall minimizes the time spent reading and identifying important material and maximizes the time available for actual learning. As part of Lippincott Williams & Wilkins' Recall Series, Pharmacology Recall uses the concise, two-column question-and-answer format to facilitate quick learning. Common Board questions and mnemonics appear throughout the book to facilitate memorization and illustrations are provided to clarify important concepts. As an additional aid, a Pharmacology Power Review is included. This chapter presents a unique "bird's eye" view of pharmacology and can be used to review large amounts of high-yield information quickly before medical school and USMLE exams.

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Annual Review of Pharmacology and Toxicology, Volume 48 (2008)

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Lippincott's Illustrated Reviews: Pharmacology, 4th Edition

Lippincott's Illustrated Reviews: Pharmacology, Fourth Edition enables rapid review and assimilation of large amounts of complex information about the essentials of medical pharmacology. Clear, sequential pictures of mechanisms of action actually show students how drugs work, instead of just telling them. As in previous editions, the book features an outline format, over 500 full-color illustrations, cross-references to other volumes in the series, and over 125 review questions. Content has been thoroughly updated, and a new chapter covers toxicology. New to this edition will be a companion Website containing all of the illustrations, fully searchable text, and an interactive question bank.

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Progress in Medicinal Chemistry : Volume 29

Hardbound. The 29th volume of the series presents yet again, an exemplary survey of a wide range of current topics in medicinal chemistry and pharmacology. Eight expert reviews emphasize the relationships between chemical structure and pharmacological activity. These detailed discussions of some of the most exciting developments in the field today, will prove of great value to future research. The book begins with a study of anti-inflammatory activities of 5-lipoxygenase inhibitors, followed by an overview of the antiarrhythmic therapeutic possibilities offered by Class III electrophysiological agents. Structures and activities of some opioid ligands are surveyed, and the investigation into pharmacologically active pyridazine derivatives is continued. Dopamine D2 receptor agonists offer exciting therapeutic potential, as do ondansetron and related 5-HT3 antagonists. The herbal origin of many modern drugs is yet again reflected in a survey.

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A Pharmacology Primer, Third Edition: Theory, Application and Methods

This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.

The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal.

At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches a course for their research scientists and has drawn on his experience to create a pharmacology primer.

*New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance.

*Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member.

*Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles.

*Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.

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Safety Pharmacology In Pharmaceutical Development And Approval

Providing detailed coverage of an emerging discipline within the pharmaceutical industry, Safety Pharmacology in Pharmaceutical Development and Approval lays out exactly the whys and hows of safety pharmacology testing. The book covers the background, history, and concerns that have evolved from lackluster safety pharmacology activities in the past. It details regulatory requirements, provides comprehensive information on study designs, and covers both the required battery of studies and the supplemental, follow-up battery. The author addresses how best to implement ICH safety standards and how to integrate pharmacology safety evaluations into existing safety evaluations.

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Encyclopedia of Molecular Pharmacology, 2nd edition

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

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cGMP: Generators, Effectors and Therapeutic Implications

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

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Medical Pharmacology at a Glance, 4th Edition

"Medical Pharmacology at a Glance" is one of the most renowned undergraduate texts in the field of medical pharmacology. Following on from the success of the previous three editions, Professor Michael Neal, one of the great teachers of medical pharmacology, has extensively revised and updated the fourth edition to take account of the rapid developments in the field. This incredibly useful book summarises the core principles of the mode of action of drugs and puts this information within the context of body systems and specific clinical problems. The author discusses the mechanisms of action of each drug, indicating the therapeutics of choice for specific conditions. "Medical Pharmacology at a Glance" follows the now familiar, easy-to-use double page spread format of the at a Glance series. Each section contains a clear illustration depicting the major drugs and their interaction within a particular body system and a concise account of the topic. Key features of the fourth edition include: new material on anti-platelet drugs in the cardiovascular section; new section on immunological drugs; new material on general anaesthetic and anti-viral drugs; and the use of Recommended International Non-proprietary Names (rINN) for drugs. "Medical Pharmacology at a Glance" is ideal for pharmacology revision and for use during clinical placements. It is an essential buy for medical students and scientists requiring a succinct and lucid account of medical pharmacology.

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Color Atlas of Pharmacology, 3rd Edition

Updated with the most important new substances and scientific developments, the third edition of The Color Atlas of Pharmacology makes it easier than ever for students, nurses, and practicing physicians to keep up with the latest developments in this constantly changing field. Featuring a user-friendly layout, jargon-free language, and more than 160 spectacular color charts and illustrations, the atlas is divided in to four, color-coded sections:

Part 1 - General pharmacology - includes descriptions of substance formulation, absorption, distribution, elimination, and molecular mechanisms of action Part 2 - Systems pharmacology - with special emphasis on the functional and therapeutic aspects of a wide range of medicinal agents Part 3 - Therapy of selected diseases - such as osteoporosis, acute myocardial infarction, migraine, asthma, tropical diseases, and many more Part 4 - Drug Index - helpfully listed by substance, generic, and brand names

Concise, portable, and packed with information, the third edition of The Color Atlas of Pharmacology is the most practical first-stop reference for today's busy healthcare professional.

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Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics: Homogeneous and Heterogeneous Approaches

The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

This timely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.

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Cyclic Gmp: Synthesis, Metabolism, and Function

This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.

Key Features
* Isoforms of guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis
* Cyclic GMP-dependent protein kinase
* Hormones and ligands that regulate GMP formation and/or metabolism
* Effects of cyclic GMP on other second messengers and some functions such as smooth muscle relaxation and ion transport
* Clinical studies with cyclic GMP and atrial natriuretic peptide
* Important questions and experiments for the future.

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